The Science of Antiaging: Advances in Chemical Age Reversal

Sunday - July 23 2023, 16:33 UTC - 1 year ago

Aubrey De Grey has been a leader in advocating, fundraising and advancing the science of Antiaging technology for the past three decades. David Sinclair at Harvard has been working on chemically reversing cellular aging and has come up with small molecules that can kill old, dysfunctional senescent cells. Various strategies for cellular reprogramming, genetic and molecular mechanisms including epigenetics are currently being studied to emulate youthful beings. Antiaging treatments are set to become more individualized and personalized in the near future.

Aubrey de Grey has been a primary leader advocating, fundraising and advancing the science of Antiaging technology for the past three decades. He provided his comment on the work of Harvard’s David Sinclair for chemically reversing cellular aging.The work in 2018 that small molecules could kill zombie, dysfunctional old senescent cells has led to the creation of many biotech companies working on senescent cells. The drugs used to treat senescent cell are called synolytics.

Rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means. Sinclair and his team developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. Recent findings show that drugs such as rapamycin and metformin may slow down the aging process and naturally increase lifespan. Senolytic drugs are used to target senescent cells, which normally impede the rejuvenation of healthy tissue. Various antiaging strategies using cellular reprogramming, genetic therapies, and other molecular mechanisms including epigenetics are currently being studied. Cellular senescence can be induced through processes such as oxidative stress, telomere shortening, and mitochondrial dysfunction. Calorie restriction and a Ketogenic diet can promote Healthy Longevity as they have shown important antiaging effects in animal studies. Various natural compounds including resveratrol, curcumin, and melatonin also show antiaging potential.

The fast-evolving field of antiaging research has led to significant advances in our understanding of emulating youthful beings rather than simply slowing down the aging process. As the science progresses, treatments are moving towards being individualized and personalized depending on the age and lifestyle of each person. With further investment in research and development, there is potential for age reversal treatments to become available by 2024.