The Role of Lipids and Skin Bacteria in Maintaining the Skin Barrier

Wednesday - September 6 2023, 09:19 UTC - 1 year ago

We studied the role of lipids and skin bacteria in maintaining the skin barrier in the Gallo Lab at the University of California, San Diego. Our research showed that C. acnes triggers certain skin cells to significantly increase production of lipids that are important to maintaining the skin barrier, and produces a type of short-chain fatty acid called propionic acid which creates an acidic skin environment which provide a number of benefits such as limiting pathogen growth, reducing staph infections and contributing to anti-inflammatory effects.

The skin is the largest organ of the body, and it plays a crucial role as the first line of defense against pathogens and insults from the external environment. It provides important functions like temperature regulation and moisture retention. And despite the misconception that lipids harm your skin by causing oiliness and acne, they actually play a vital role in maintaining the skin barrier.

Lipids – organic compounds that include fats, oils, waxes and other types of molecules – are essential components of the outermost layer of skin. Changes to the skin’s lipid composition can disrupt its ability to function as a protective barrier, leading to a range of skin diseases, including eczema and psoriasis.

Human skin is colonized by thousands of species of bacteria. One of the most common microbes on the skin, Cutibacterium acnes, or C. acnes, is well known for its potential involvement in causing acne, but its broader effects on skin health are less understood.

I am a researcher in dermatology working in the Gallo Lab at the University of California, San Diego. My colleagues and I study how the skin defends the body against infections and the environment, with a particular focus on the skin microbiome, or the microbes living on the skin. In our recently published research conducted in collaboration with SILAB, a company developing active ingredients for skincare products, we found that C. acnes triggers certain skin cells to significantly increase production of lipids that are important to maintaining the skin barrier.

Skin bacteria and lipid synthesis .

To determine the role that bacteria play in lipid production, we exposed keratinocytes, the cells that make up the epidermis, to different bacteria naturally present on the skin and analyzed changes in lipid composition.

Of the common skin bacteria we tested, only C. acnes triggered an increase in lipid production within these cells. More specifically, we found a threefold increase in total lipids, including ceramides, cholesterol, free fatty acids and especially triglycerides. Each of these lipid types are essential to maintaining the skin barrier, locking in moisture and protecting against damage. These findings suggest that C. acnes plays a distinctive role in the lipid skin regulation.

We found that C. acnes induced this increase in lipid production by producing a type of short-chain fatty acid called propionic acid. Propionic acid creates an acidic skin environment that provides a number of benefits, including limiting pathogen growth, reducing staph infections and contributing to anti-inflammatory effects in the gut.

We also identified the specific gene and receptor that regulate lipid synthesis through C. acnes. Blocking these components also blocked C. acnes-induced lipid synthesis.

In all, our findings highlight the substantial role that a common skin bacterium and its chemical byproducts play in shaping the composition of skin lipids.

Reinforcing the skin barrier .

Our research suggests that propionic acid from C. acnes has multiple advantageous effects on the skin barrier. For example, by increasing the lipid content in skin cells, propionic acid plays a role in preventing the loss of moisture. It also contributes to the skin’s structure by reducing inflammation and inhibiting the growth of dangerous and potentially pathogenic bacteria.