The Potential to Reverse Aging: Promise of Alpha-ketoglutarate and Repurposed Drugs for Human Healthspan

Tuesday - May 9 2023, 22:38 UTC - 1 year ago

Rejuvant has conducted human medical studies where aging biomarkers have been reversed to reduce measured biological age. Professor Brian Kennedy and Professor Andrea Maier at the Centre for Healthy Longevity at Alexandra Hospital are executing studies to test novel nutritional supplements and repurposed drugs to slow aging. Alpha-ketoglutarate, metformin, and strength training have been identified as potential interventions.

I, Brian Wang, have started taking Rejuvant time released AKG. AKG is safely used by millions for bodybuilders and athletes. Time-released AKG from Rejuvant is used for healthier aging.

Rejuvant has human medical studies where aging biomarkers have been reversed to reduce measured biological age. There is more than the single case as the study looked at hundreds of people.

This chart shows the measurements. There are error bars but the midpoints indicate that over a three 6 months courses of using Rejuvant every day he has his measured biologial age reduce from 52 down to 45. If this is accurate, then it would suggest he is squaring the health curve. According to biomarkers he is getting substantially healthier.

I would interpret effect to mean that people can be far healthier up to 80 to 95 but then aging damage still reaches critical levels to cause aging diseases.

I would cite the example of the fitness guru, Jack LaLanne. Jack was fanatical about eating right and exercising. Jack has amazing feats of fitness into his 80s. .

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Antiaging Studies and Investigation .

Brian Kennedy indicates he agrees with the Aubrey dr Grey / SENS analysis of seven kinds of aging damage.The first research theme funded under the ‘Hacking Aging’ initiative is a series of clinical studies to test novel nutritional supplements and repurposed drugs to slow ageing in middle-aged adults (40-60 years).

At least 15 biomarker studies are ongoing, including Project Abios (Ageing Biomarker Study in Singaporeans) which is looking at several hundred biomarkers in 420 to 450 participants.

The second research theme is to use deep omics data to personalize these supplements and repurposed drugs and other interventions for optimal healthspan extension in middle-aged participants.

One of the supplements is alpha-ketoglutarate, which has been shown to increase the healthspan – the period of life spent in good health – and lifespan in mice. The centre will be investigating whether six months of daily supplementation can slow biological aging and initial results are estimated to be available in a year’s time, said Professor Andrea Maier, the centre’s co-director. Repurposed drugs include metformin, a well-known drug used to treat Type 2 diabetes, that may be able to slow ageing.

The third research theme focuses on extending healthspan in older adults through strength training exercise, harnessing the Foundation’s Gym Tonic community of seniors.

Professor Brian Kennedy, internationally recognized for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases, is helming the Centre with co-director, Professor Andrea Maier, an internal medicine specialist renowned for translational research in aging and age-related diseases diagnostics and pharmacological and non-pharmacological interventions in aging humans.

The 1,600 square feet Centre for Healthy Longevity (CHL) located at Alexandra Hospital, will conduct trials and execute validation studies with healthy participants from the age of 30 years. The Centre will also develop and test these interventions using newly identified biomarkers of human aging and age-related diseases.