Immediately Expand Research on Extending Healthy Human Lifespans

Wednesday - October 11 2023, 15:52 UTC - 1 year ago

Immediately Expand Research on Extending Healthy Human Lifespans is an urgent call for the scientific community to invest in research resources and develop a common understanding for unlocking the vast potential of extending healthy lifespans.By gathering together experts from diverse fields, we should examine strategies to target aging processes, aging-related diseases, and identify novel approaches for altering the course of age-associated decline to extend healthy lifespans.

Demonstrating both expert consensus and broad public support for the extension of healthy lifespans will have the greatest impact in swaying policymakers and institutions to acknowledge and align with the paradigm shift now taking root across medical science.Sign your support to Immediately Expand Research on Extending Healthy Human Lifespans.

Some Emerging Strategies and Questions: .

Combinatorial approaches – Can multiple systems be targeted simultaneously and will that yield synergistic outcomes? .

Novel classes of small molecules – We have only explored a narrow subset of the small-molecule space for longevity outcomes.Will larger-scale screens or even novel screening approaches result in enhanced lifespan extension? .

Cellular reprogramming – Can we reprogram somatic cells in our tissues to a state to promote replacement of damaged cells and restoration of youthful tissue function? .

Approaches based on species longevity – Can we utilize adaptations of long-lived species to achieve human longevity comparable to nature’s greatest successes, exceeding the modest changes delivered by existing interventions? .

Gene and cell therapy – Long promised, both gene therapy and cell therapy have become feasible.Can they be employed to target aging or age-related conditions? .

Novel targets – for example, gene therapies derived from multi-omics studies.Can they delay or reverse aging processes? .

Emerging strategies to reverse age-related deterioration of the epigenome – There is good evidence that this deterioration reduces our control of endogenous parasites such as retrotransposons and retroviruses and increases age-related inflammation.Can it be repaired? .

Personalizing aging interventions – While general events are likely to drive aging, their relative impacts in each individual are likely to vary, therefore understanding how to optimize interventions to the individual will likely have higher yields.

Over the horizon – Often regarded as science fiction, strategies such as cryopreservation, brain mapping and ex vivo organ generation may ultimately be feasible.We should keep open the possibility that dramatic lifespan extension may involve technologies that we haven’t fully imagined yet.

Immediately Expand Research on Extending Healthy Human Lifespans is an urgent call for the scientific community to invest in research resources and develop a common understanding for unlocking the vast potential of extending healthy lifespans.The aim of this effort is to stimulate research and funding towards therapies for treating or reversing the aging process.By gathering together experts from diverse fields, we should examine strategies to target aging processes, aging-related diseases, and identify novel approaches for altering the course of age-associated decline to extend healthy lifespans.We need to continue to push the boundaries to learn strategies that encourage longevity and prevent or delay age-associated diseases.Our collective knowledge and resources should be brought together to develop a comprehensive plan that includes new types of medical treatments and extends the lives of tomorrow’s patients.Together, we can significantly accelerate progress towards understanding how longevity works and how to apply these findings to achieve healthier longer lives.