Genetic Variants Affecting Hair Whorl Direction Revealed

Thursday - August 17 2023, 07:31 UTC - 1 year ago

The first gene mapping study on human scalp hair whorls uncovers multiple genes that influence hair whorl direction. Four associated genetic variants are identified, and it is proposed that they influence the direction by regulating the cell polarity of hair follicles and cranial neural tube closure and growth. Previous work also proposed the hypothesis of associations between hair whorl patterns and abnormal neurological development, but no significant genetic associations were observed.

A new study in the Journal of Investigative Dermatology uncovers the genes that dictate the direction of hair whorls. The first gene mapping study on human scalp hair whorls not only demonstrates that hair whorl direction has a genetic basis, but also that it is influenced by multiple genes. Four associated genetic variants that are likely to influence hair whorl direction are identified, as reported in the Journal of Investigative Dermatology, published by Elsevier.

A hair whorl is a patch of hair growing in a circular pattern around a point defined by hair follicle orientations. Scalp hair whorl pattern, a readily observable human trait, is usually characterized by the whorl number (single or double whorl) and whorl direction (e.g., clockwise, counterclockwise, or diffuse). Because atypical whorl patterns have been observed in patients with abnormal neurological development, comprehending the genetic foundation of whorl patterns might help shed light on vital biological processes.

The first genome-wide association study (GWAS) on human scalp hair whorls was conducted among 2,149 Chinese individuals from the National Survey of Physical Traits cohort. This was followed by a replication study in 1,950 Chinese individuals from the Taizhou Longitudinal Study cohort. Lead investigator Sijia Wang, PhD, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, explained, "We know very little about why we look like we do. Our group has been looking for the genes underlying various interesting traits of physical appearance, including fingerprint patterns, eyebrow thickness, earlobe shape, and hair curliness. Hair whorl is one of the traits that we were curious about. The prevailing opinion was that hair whorl direction is controlled by a single gene, exhibiting Mendelian inheritance. However, our results demonstrate that hair whorl direction is influenced by the cumulative effects of multiple genes, suggesting a polygenic inheritance." .

The study identifies four associated genetic variants (at 7p21.3, 5q33.2, 7q33, and 14q32.13). These genetic variants are likely to influence hair whorl direction by regulating the cell polarity of hair follicles. Additionally, cranial neural tube closure and growth could play a part in this process.

Professor Wang continued, "While previous work proposed the hypothesis of associations between hair whorl patterns and abnormal neurological development, no significant genetic associations were observed between hair whorl direction and behavioral, cognitive, or neurological phenotypes. Although we still know very little about why we look like we do, we are confident that curiosity will eventually drive us to the answers." .