COVID-19 Vaccines Linked With Slight Increase in Menstrual Bleeding Quantity

Category Science

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A new international study from the British Journal of Obstetrics and Gynecology has found that women vaccinated for COVID-19 have a slightly higher risk for a heavier period after vaccination, though the changes are small and typically return to normal in the next menstrual cycle.

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A recent study found a slightly higher risk of heavier periods after COVID-19 vaccination. Researchers emphasize that the changes are small and typically return to normal in the next menstrual cycle.

A new international study finds that women vaccinated for COVID-19 have a slightly higher risk for a heavier period after vaccination.

The study, led by Oregon Health & Science University reproductive health services researcher Blair Darney, Ph.D., M.P.H., and physician-scientist Alison Edelman, M.D., M.P.H., published recently in the British Journal of Obstetrics and Gynaecology. These findings build on prior work from the same research team that first identified an association between COVID-19 vaccines and menstrual cycle changes.

The study utilized data from the fertility tracking app Natural Cycles.

While there is a growing body of evidence demonstrating that COVID-19 vaccination is associated with a small increase in cycle length, other disturbances such as bleeding quantity are less well known. This study aimed to estimate the effect of COVID-19 vaccination on menstrual bleeding quantity among individuals with normal menstrual cycles.

"Menstruation is a routine bodily function and a key indicator of overall health, so it’s crucial that we understand the scope of this issue among the global population," said Edelman, one of the study’s lead authors. "The more we can understand about these reported changes, the more effectively we’re able to counsel individuals about what to expect with a COVID-19 vaccine and how to make an informed decision about getting vaccinated." .

Women experienced a 4% increase in total bleeding quantity after their first COVID-19 vaccine dose.

In a retrospective cohort study, researchers analyzed menstrual cycle data from the fertility tracking app Natural Cycles. The cohort included a total of 9,555 individuals — 7,401 vaccinated and 2,154 unvaccinated — primarily living in the United States, Canada, the United Kingdom and Europe. Participants reported daily bleeding quantity as "spotting," "light," "medium" or "heavy." Researchers then examined the number of heavy bleeding days and total bleeding quantity.

Changes in menstrual bleeding are typically temporary, resolving in the cycle after vaccination.

Analyses showed a small — 4% — increase in the percentage of participants who experienced greater total bleeding quantity following the first COVID-19 vaccine dose compared with an unvaccinated comparison group. This difference translates to an estimated 40 additional people per 1,000 normally cycling individuals who experienced more bleeding quantity. Researchers also found that these changes typically resolved by the first post-vaccination menstrual cycle.

The research team suggests that these findings should reassure individuals rather than cause concern.

The research team emphasizes that these findings shouldn’t be a cause for concern, but should validate the public’s experiences and provide reassurance that, if changes in flow occur with vaccination, they are likely to be small and temporary.

"Experiencing an unexpected change in your menstrual cycle can be alarming," Darney said. "We hope this research can assure individuals that they are heard and their experiences around menstruation are valid. As was discovered in previous research, these changes at a population level are small, typically resolving in the cycle after vaccination, and generally shouldn’t be a source of anxiety or fear." .

The study did not investigate why these changes occur, however, possible mechanisms have been proposed.

Individuals who notice prolonged changes in menstruation are encouraged to seek guidance from their clinician.

While this study didn’t look at why these changes occur, researchers note that there are several pliable mechanisms from prior research that could explain this phenomenon, including a brief disruption of endocrine hormones and the body’s inflammatory response.

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